New economic and shopper realities have forever altered the US drugstore landscape by serving as a catalyst to speed a transformation which began several years ago. While some questions about the future direction of Walgreens, CVS, and Rite Aid have been answered, many more have been raised. Yet one thing is clear; these transformational changes are taking hold, gaining momentum—and ushering in a more dynamic, complex, and competitive operating environment for all involved. Future success in this channel will require deeper strategic alignment and collaboration, new skill sets and team resources—and above all, a fresh perspective anchored in shopper insights.